Press & Publications

Cranberry products are among most popular herbal dietary supplements, and their economic adulterations are a cause for a serious concern. MALDI-TOF MS is an advanced analytic tool that provides several significant advantages over more conventional techniques, including unparalleled throughput and speed of analysis, as well as specificity and accuracy.

This article from Nutraingredients.com (10-Aug-2016 By Hank Schultz) explains the way Complete Phytochemical Solutions helped develop a new standard for cranberry testing. The Cranberry Institute has issued a new specification on cranberry powder to be used in research studies in an effort to better coordinate clinical trial results on this increasingly popular botanical.

• Identification of Adulterants in Cranberry Foods and Dietary Supplements by MALDI-TOF MS.
• C&EN: Rapid Authentication of Foods, Beverages and Dietary Supplements by MALDI-TOF MSE. coli. Polewski et al., 2016.
• Live Demo On-Demand Authentication of the Botanical Origin of Dietary Ingredients by MALDI TOF MS.

• Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015. Blumberg et al., 2016.
• Non-covalent pomegranate (Punica granatum) hydrolyzable tannin-protein complexes modulate antigen uptake, processing and presentation by a T-cell hybridoma line co-cultured with murine peritoneal macrophages. Madrigal-Carballo et al., 2016.
• Ability of cranberry proanthocyanidins in combination with a probiotic formulation to inhibit in vitro invasion of gut epithelial cells by extra-intestinal pathogenic E. coli. Polewski et al., 2016.
• Critical reevaluation of the 4-(dimethylamino)cinnamaldehyde assay: Cranberry proanthocyanidin standard is superior to procyanidin A2 dimer for accurate quantification of proanthocyanidins in cranberry products. Krueger et al., 2016.

• Methods to determine effects of cranberry proanthocyanidins on extraintestinal infections: Relevance for urinary tract health. Feliciano et al., 2015
• Fluorescent labeling of cranberry proanthocyanidins with 5-([4,6-dichlorotriazin-2-yl]amino)fluorescein (DTAF). Feliciano et al., 2015.

• Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update.Rodriguez-Mateos et al., 2014.
• Validation of HPLC assay for the Identification and Quantification of Anthocyanins in Black Currants. Chen et al., 2014.
• Supercritical Fluid Extraction (SFE) of Cranberries Does Not Extract Oliomeric Proanthocyanidins (PAC) but Does Alter the Chromatography and Bioactivity of PAC Fractions Extracted from SFE Residues. Feliciano et al., 2014.
• Ratio of “A-type” to “B-type” Proanthocyanidin Interflavan Bonds Affects Extra-intestinal Pathogenic Escherichia coli Invasion of Gut Epithelial Cells. Feliciano et al., 2014.
• Development and Phytochemical Characterization of High Polyphenol Red Lettuce with Anti-Diabetic Properties. Cheng et al., 2014.
• Cranberry Proanthocyanidins Improve Intestinal sIgA During Elemental Enteral Nutrition. Pierre et al., 2014.

• Quantifying and Characterizing Proanthocyanidins in Cranberries in Relation to Urinary Tract Health. Krueger et al., 2013.
• Consumption of Sweetened, Dried Cranberries May Reduce Urinary Tract Infection Incidence in Susceptible Women – A Modified Observational Study. Burleigh et al., 2013.
• Parenteral Nutrition Increases Susceptibility of Ileum Invasion by E. coli. Pierre et al., 2013
• Cranberry Proanthocyanidins Improve the Gut Mucous Layer Morphology and Function in Mice Receiving Elemental Enteral Nutrition. Pierre et al., 2013.
• Concorde Grape Pomace Polyphenols Complexed to Soy Protein Isolate are Stable and Hypoglycemic in Diabetic Mice. Roopchand et al., 2013.
• Food-compatible Method for the Efficient Extraction and Stabilization of Cranberry Pomace Polyphenols. Roopchand et al., 2013.

• Deconvolution of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry isotope patterns to determine ratios of A-type to B-type interflavan bonds in cranberry proanthocyanidins. Feliciano et al., 2012
• Comparison of Isolated Cranberry (Vaccinium macrocarpon Ait.) Proanthocyanidins to Catechin and Procyanidins A2 and B2 for Use as Standards in the 4-(Dimethylamino)cinnamaldehyde Assay. Feliciano et al., 2012.
• Differential effects of grape (Vitis vinifera) skin polyphenolics on human platelet aggregation and low-density lipoprotein oxidation. Shanmuganayagam et al., 2012
• Comparison of Isolated Cranberry (Vaccinium macrocarpon Ait.) Proanthocyanidins to Catechin and Procyanidins A2 and B2 for Use as Standards in the 4-(Dimethylamino)cinnamaldehyde Assay.MALDI-TOF mass spectrometry of oligomeric food polyphenols. Reed JD, Krueger CG,Vestling MM.
• A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Howell AB, Reed JD, Krueger CG, Winterbottom R, Cunningham DG, Leahy M.
• Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of heteropolyflavan-3-ols and glucosylated heteropolyflavans in sorghum [Sorghum bicolor (L.) Moench]. Krueger CG, Vestling MM, Reed JD.
• Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of polygalloyl polyflavan-3-ols in grape seed extract. Krueger CG, Dopke NC, Treichel PM, Folts J, Reed JD.